Clinical Observation of Acute Delayed Neurotoxicity of Tri Ortho Cresyl Phosphate in Adult Hen

Clinical observation of acute delayed neurotoxicity study for 21 days of organophosphate using triorthocresyl phosphate (TOCP) as a model for organophosphate neurotoxicity, adult hens were dosed by oral gavage with 500mg/kg/bw single dose. Treated hens showed varying degrees of in-coordination, ataxia and paralysis at varying grades and on varying days of treatment mostly depending on the various metabolisms of the neurotoxic compound by the individual bird. Aggrading was suggested reflecting the severity of the effect on different hens and that was from 1 to 6, therefore birds with slight in-coordination were considered to be 1 to 2, those with ataxia were considered to be 3 to 4 and those with paralysis were considered 5 to 6. Some birds with the paralysis died because of starvation as they could not feed themselves.